Greenlandic Inuit show genetic signatures of diet and climate adaptation. The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega- 3 polyunsaturated fatty acids (PUFAs). Greenlandic Inuit show genetic signatures of diet and climate adaptation. Science, 18 September 2015 DOI: 10.1126/science.aab2319. Adaptation to high-fat diet, cold had profound effect on Inuit, including shorter height: Greenlanders developed unique. Use the following search parameters to narrow your results: subreddit:subreddit find submissions in 'subreddit' author:username find submissions by 'username' site:example.com find submissions from 'example.com' url:text search for 'text' in url selftext:text. The indigenous people of Greenland, the Inuit, have lived for a long time in the extreme conditions of the Arctic, including low annual temperatures, and with a specialized diet rich in protein and fatty acids, particularly omega-3 polyunsaturated fatty acids (PUFAs). A scan of Inuit genomes for. A scan of Inuit genomes for signatures of adaptation revealed signals at several loci, with the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels. The selected alleles are associated with multiple metabolic and. A scan of Inuit genomes for signatures of adaptation revealed signals at several loci, with the strongest signal located in a cluster of fatty acid desaturases that determine PUFA levels. The selected alleles are associated with multiple metabolic and anthropometric phenotypes and have large effect sizes for weight and height, with the effect on height replicated in Europeans. By analyzing membrane lipids, we found that the selected alleles modulate fatty acid composition, which may affect the regulation of growth hormones. Thus, the Inuit have genetic and physiological adaptations to a diet rich in PUFAs. Another study found evidence that adaptation to the traditional hypoglycemic diet of Greenlandic Inuit may have favored a mutation in TBC1D4 that affects glucose uptake and occurs at high frequency only among the Inuit ().This region is thought to be central to cold adaptation by generating heat from a specific type of body fat. Greenlandic Inuit show genetic signatures of diet and climate adaptation. Science, 2015; 349 (6254): 1343 DOI: 10.1126/science. Greenlandic Inuit show genetic signatures of diet and climate adaptation Science September 2015 M. Greenlandic Inuit show genetic signatures of diet and climate adaptation. Greenlandic Inuit show genetic signatures of diet and climate adaptation Matteo Fumagalli, Ida Moltke, Niels Grarup, Fernando Racimo, Peter Bjerregaard.
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